because when the Spanish came to the Americas they brought diseases with them. These diseases killed large numbers of Native Americans. These diseases also killed off the Natives food sources. The Spanish also had fire power which allowed them do dominate the battles they fought. Where the Native Americans had wooden spears, bows, arrows, etc. They used stone as arrrrow heeds. Thaiss allowed the Spanish to easily conquer the Aztecs and the Incans.
hope this helps :)