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The number of which subatomic particle changes to create an isotope?

User Bondt
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It is the neutrons (uncharged particles) in the nucleus which change to form an isotope.
User Xcecution
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When we go from one isotope to another, it is the nucleus that changes. Isotopes are atoms of the same element with different masses. Carbon-12 has 6 protons and 6neutrons.
User Lionel Rowe
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