Question

Which of the following would produce a nonsense mutation?

A. The replacement of a single base, producing the same amino acid B. The deletion of a single base C. The insertion of a single base D. The replacement of a single base, producing a stop codon

Answer 1

D because stop codon would change the entire protein causing almost everything as a whole to be different. All in all everything becomes nonsense compared to the original base sequence

Answer 2

(D). The replacement of a single base, producing a stop codon.

Step-by-step explanation:

Mutations represent permanent changes in genetic material due to alteration in DNA sequences. A mutation converts a sense codon (codon that codes for a particular amino acid) to a stop codon, is known as nonsense mutations.

It leads to formation of a non-functional and truncated protein as due to stop codon translation halts in middle.

Thus, the correct answer is option (D).