Final answer:
The region where witch-hunting was at its peak between 1580-1662 was New England, specifically in Salem Village during the Salem Witch Trials.
Step-by-step explanation:
The Salem Witch Trials occurred in the colonial Massachusetts. A series of hearings and prosecutions led to the execution of 20 people accused of witchcraft. Driven by religious and social tensions, the trials reflected mass hysteria, fear, and a tragic chapter in American colonial history.
The region where witch-hunting was at its peak between 1580-1662 was New England, specifically in Salem Village. During this time, there was a mass hysteria known as the Salem Witch Trials, where many individuals, mostly women, were accused and executed for witchcraft. The Puritan belief system and societal factors contributed to the widespread accusations and executions.