No, they are not related to each other.
Vince Vaughn was an American actor, producer, screenwriter, and comedian, with a net worth of $30 million, whereas, Matthew Vaughn was a producer, director, and screenwriter with a net worth of around $25 Million. Matthew Vaughn is known for movies like X-men etc. and Vince Vaughn is known for movies like Wedding Crashers, Internship etc.