1) Perform an ABO/RH on a mother to determine her Rh factor. If she is Rh negative she may be a candidate for Rhogam after giving birth to a Rh positive infant.
2) Perform an ABO/RH, antibody screen and crossmatch on a bleeding patient.
3) Perform an ABO/RH and a HLA (human leukocyte antigen) type on a patient needing an organ transplant.