Not sure if you mean to ask for the first order partial derivatives, one wrt x and the other wrt y, or the second order partial derivative, first wrt x then wrt y. I'll assume the former.


Or, if you actually did want the second order derivative,
![(\partial^2)/(\partial y\partial x)(2x+3y)^(10)=\frac\partial{\partial y}\left[20(2x+3y)^9\right]=180(2x+3y)^8*3=540(2x+3y)^8](https://img.qammunity.org/2018/formulas/mathematics/college/cpx7j3co1labgue4yjw2rb3u48c45hx4my.png)
and in case you meant the other way around, no need to compute that, as

by Schwarz' theorem (the partial derivatives are guaranteed to be continuous because

is a polynomial).