Prokaryotes only: cell wall contains peptidoglycan or pseudomurein; binary fission; 70S ribosomes; singular circular chromosome.
Eukaryotes only: 80S robosomes; membranous organelles, including mitochondria, lysosomes , endoplasmic reticuum; nuclear envelope compartmentalizes the chromosomes.
Both prokaryotes and eukaryotes: has both DNA and RNA; plasma membrane encloses the cytoplasm; includes unicellular cells.