Question

A model cell with damaged DNA was created to explain the importance of checkpoints in a cell cycle.The G2 checkpoint accidentally Failed to work during experimentation.What do you think is the likely consequence of this failure?

a. this cell divided in created two cells with repair DNA
b. the cell couldn't divide in the cell division stopped
c.The cell died before it could complete division
d. The cell divided and created nonidentical cells
e.The cell continued to divide uncontrollably to create more damaged cells

Answer 1

E is the Answer ! The cell continued to divide uncontrollably to create more damaged cells

Answer 2

The right answer is E.

The G2 phase control point acts for the cell so that mitosis is not triggered until the replication is fully completed or until the lesions detected in the replicated DNA are repaired. For this, the intervening molecules will block the activation process of Cdk1.

Thus, the Cyclin B / Cdk 1 complex retains its inhibitory phosphorylations, or is blocked by p21, until the replication is complete: no mitosis begins before the end of the replication.

If the DNA is damaged, or if the replication is not completed, the activation of several inhibitory pathways of the Cdk 1 / Cyclin B complex makes it possible to prevent the entry into mitosis. If this inhibition is absent, then the mitosis is triggered.