Answer:
The correct answer is D. The most vocal opponent of the Tariff of 1828, who advocated "State's Rights" and "Nullification" in the growing sectional conflicts between North and South was John C. Calhoun, of South Carolina.
Step-by-step explanation:
John Caldwell Calhoun was one of the most influential politicians in US history, the chief ideologist of the slave-owning southern policy and lobbyist of state interests in the federal government. As Vice-President, he defended these ideas in the Tariffs of 1828 conflict, because of what resigned to his position. His ideas were later used to justify the secession of the southern states and the establishment of the Confederate States of America.