It doesn't differ that much.
The population density is much lower than in the Northeast. There are huge cities like Atlanta and Houston which have a typical American vibe. Of course, you'll notice the various Southern accents.
There are liberals, intellectuals and artists living everywhere. A couple of states have Indian immigrants as (right-wing) governors. Of course, there are a lot of white conservatives, but a diligent French TV crew can find them in California too.