Final answer:
The structure made of DNA packaged up with proteins is called chromatin. Chromatin is composed of DNA and associated histone proteins, which form nucleosomes. These nucleosomes further compact to form chromosomes.
Step-by-step explanation:
The structure made of DNA packaged up with proteins is called chromatin. Chromatin is composed of DNA and associated proteins called histones. The DNA is tightly wrapped around the histone proteins to form structures called nucleosomes, which resemble 'beads on a string'. These nucleosomes further compact to form a 30-nm fiber, and during metaphase, the chromatin condenses into chromosomes.