Final answer:
To act upon genetic variations, natural selection requires that these variations are expressed in the organism's phenotype, thereby affecting its survival and reproduction.
Step-by-step explanation:
Genetic variations are essential for the process of evolution. For natural selection to act upon these variations, the key factor is that the genetic variations must be expressed in the phenotype of the organism.
Phenotypic expression of genetic variations means that the differences caused by the genes can influence an organism's chances of survival and reproduction within a given environment. Thus, the correct answer to the student's question is: d. the genetic variations are in the phenotype of the organism.