Question

In class we also talked about the metabolism of HDL particles.

a. The metabolism of HDL involves the formation of immature HDL particles in the liver.
b. These immature HDL particles (nascent HDL) contain only a small amount of cholesterol and no cholesteryl esters.
c. As HDL particles circulate through the bloodstream, they are transformed into mature HDL particles by picking up extra cholesterol from cholesterol-rich extrahepatic cells.
d. This process is called reverse cholesterol transport.
e. The number of mature HDL particles in circulation is inversely proportional to cardiovascular disease and atherosclerosis.
Please describe the basis of this inverse relationship.

Answer 1

Step-by-step explanation:

The basis for the inverse relationship between number of matured HDL in circulation and and cardiovascular disease is that when new HDL entertainment circulation they mature by picking up extra cholesterol until they become mature and high cholesterol level is a major cause of cardiovascular disease and atherosclerosis. The implication of this is that the more the number of matured HDL in circulation, the lower the cholesterol level in the blood thus the lower the risk of cardiovascular disease and atherosclerosis.