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Adding what groups to histones tightens the DNA and prevents transcription.

User Noah Passalacqua
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Answer: Addition of methyl groups to histones by histone methyltransferases, can either activate or further repress transcription, depending on the amino acid being methylated and the presence of other methyl or acetyl groups in the vicinity. The fundamental unit of chromatin, called a nucleosome, contains DNA wound around a protein octamer.

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User Tomdelahaba
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