Answer:
A difference between spironolactone and hydrochlorothiazide is that with the first one the amount of potassium that is lost through urine is smaller than with hydrochlorothiazide.
Step-by-step explanation:
Spironolactone and hydrochlorothiazide are two different types of diuretics, the main difference between these two is that the spironolactone is a diuretic that prevents the absorption of high quantities of salt and also keeps the potassium levels low while hydrochlorothiazide only prevents the absorption of too much salt avoiding fluid retention.