Two neurons always joined axon end to dendrite end. Two neurons are connected through synapses.
Explanation:
Synapses are the points between two neurons that allows them to communicate signals to one another. The signal may be chemical or electrical. The chemical synapse uses chemical messages as a signal to another synapse, while the electrical synapse sends ions as a signal to another synapse.
A single cell can have a varied number of synapses. They are formed when an axon branches out to create communication sites from where a signal is to be sent.