Answer:
C. Because of the religious differences: England had officially broken with the Roman Catholic Church while Spain was devoutly Catholic.
Step-by-step explanation:
England considered Spain as its enemy by the late 1500s because of its religion difference. England maintains hostile toward Catholic since Henry VIII of England split from Rome papacy and its Church by declaring himself as of the Church of England. The tension between England and Spain rise in 1585 when Queen Elizabeth I reclaimed protestant religious in its country. Philip II of Spain as a devoted Catholic was not happy with Elizabeth I decision. He wanted to restore the Catholic by pushing out Protestant in the country.