Question

Acetyl-CoA can be generated by which three metabolic pathways for potential use by the Citric Acid Cycle for energy metabolism?

a) Glycolysis, Gluconeogenesis, Fatty acid oxidation
b) Gluconeogenesis, amino acid degradation, fatty acid oxidation
c) Glycolysis, amino acid degradation, fatty acid oxidation
d) Glycolysis, amino acid synthesis, fatty acid oxidation
e) Glycolysis, cholesterol degradation, fatty acid oxidation

Answer 1

The production of acetyl-CoA for the Citric Acid Cycle involves three main pathways: glycolysis, amino acid degradation, and fatty acid oxidation; therefore, the correct answer is c) Glycolysis, amino acid degradation, fatty acid oxidation.

Step-by-step explanation:

Generation of Acetyl-CoA for the Citric Acid Cycle

Acetyl-CoA can be generated by three metabolic pathways for potential use by the Citric Acid Cycle for energy metabolism. These pathways are:

• Glycolysis, where glucose is broken down into pyruvate which is subsequently converted into acetyl-CoA.
• Amino acid degradation, where amino acids are deaminated and the resulting carbon skeletons are converted into acetyl-CoA or other intermediates that enter the Citric Acid Cycle.
• Fatty acid oxidation, also known as beta-oxidation, where fatty acids are broken down to generate acetyl-CoA.

The correct answer to the question is c) Glycolysis, amino acid degradation, fatty acid oxidation.

Answer 2

C is the correct option.

Step-by-step explanation:

Glycolysis is the standard way for the formation of acetyl-CoA, from glucose.

Second, beta-oxidation of fatty acids generates 2 acetyl-coA molecules per cycle.

Finally, the degradation of amino acids generates intermediates of the Krebbs cycle. Occasionally Leucine, tryptophan and isoleucine are directly catalysed in acetyl-CoA.