Answer:
The correct option is : c. in the Mississippi river valley
Step-by-step explanation:
Histoplasmosis is a fungal infection caused by the Histoplasma capsulatum fungus. This disease mainly affects the lungs of an individual. The acute histoplasmosis is generally characterized by cough or influenza. Whereas, the symptoms of chronic histoplasmosis resemble tuberculosis.
In the United States of America, about sixty to ninety percent of the total population in Mississippi River valleys and Ohio have suffered from Histoplasmosis.
Therefore, in the United States of America, the highest number of histoplasmosis cases occur in the Mississippi River valleys and Ohio.