Question

Which of the following is NOT involved in glycogen synthesis?GlycogeninAmylo-(1,4 to 1,6)-transglycosylaseGlycogen phosphorylaseUDP-glucoseGlycogen synthase

Answer 1

The correct answer is: Glycogen phosphorylase UDP-glucose

Steps of glycogen synthesis (glycogenesis) are:

• Glucose conversion into glucose 6-phosphate by the glucokinase enzyme

• Glucose-6-phosphate conversion into glucose-1-phosphate by the phosphoglucomutase enzyme

• Glucose-1-phosphate conversion into UDP-glucose by the enzyme UDP-glucose pyrophosphorylase

• Creation of initial short glycogen chains by glycogenin

• UDP-glucose is added to the growing glycogen chain to the 4-hydroxyl group of the glucosyl residue by the glycogen synthase enzyme

• Branches are made by glycogen branching enzyme (amylo-α(1:4)→α(1:6)transglycosylase).