The correct answer to this open question is the following.
The most difficult part of the way of life for me personally if I lived in Jamestown during that period would have been the adaptation to a different rural or natural environment after living part of my life in a large European city.
Jamestown, Virginia was the first formal colony established in the North American territory by the English people. The London-Virginia company sponsored the trip to the Americas, and the idea was to exploit the raw materials and natural resources to make a profit. And that is why the first settlers tried to do.
However, it was not an easy task at first because colonists had to endure extremely cold weather, the lack of food, some diseases, and had to ask the Native American Indias of the region, help to survive under those harsh conditions.